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phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers might raise the metabolism of ifosfamide to its Energetic alkylating metabolites.Upon initiation or discontinuation of secukinumab in people who're getting concomitant CYP450 substrates, particularly Thes